MAIN INGREDIENTS AND DOSAGE: (per daily dose of 2 capsules)1

  • Edge7 Relax Formula: 680mg (contains Gamma Aminobutyric Acid, L-Theanine, Taurine)
  • Vitamin B6 (Pyridoxine HCL): 90mg (6428% Reference Intake)
  • Magnesium (Magnesium Hydroxide): 70mg (18% Reference Intake)
     

GAMMA AMINO BUTYRIC ACID

Gamma amino butyric acid (GABA) is a chemical occurring in the nervous system that reduces excitability.GABA acts by activating the natural GABA-A2 and GABA-B3 receptors in the brain, both of which are associated with anxiety reduction and relaxation.Scientific studies suggest that oral administration of GABA produces relaxing and anxiolytic effects2 on the mind, and also boosts immunity.

L-THEANINE

L-theanine is an amino acid that occurs almost exclusively in tea plants, with ample research to support its effectiveness in relaxing the mind.Studies suggest that oral intake of L-theanine causes an increase in alpha-type brain waves3 among human volunteers within 40 minutes of intake. Alpha brain waves are associated with a relaxed state of mind.Another study confirmed that L-theanine reduces both psychological and physiological parameters of stress4 in humans by increasing production of serotonin, dopamine and GABA5 in the brain cells.

TAURINE

Taurine is an organic acid present in animal tissues.Current research suggests that taurine exerts anxiolytic effects through glycine receptors of the brain6. Notably, a number of studies have shown that it has significant anti-anxiety effects at lower doses7 while higher doses were associated with sedative effects8.

VITAMIN B6

Vitamin B6, is a vitamin used by the body for a variety of functions. Several studies have found that it helps reduce anxiety.A review on the effects of various supplements concluded that the use of vitamin B6, in combination with other vitamins and minerals, effectively reduces anxiety and stress9.Similarly, vitamin B6 is shown to reduce both psychological and physiological symptoms of irritability and anxiety10.

MAGNESIUM

Magnesium is an essential mineral required by the body.Magnesium deficiency has been linked to several psychological symptoms, including anxiety11 and depression12.Supplementation of magnesium alone or in combination with vitamin B6 has also been reported to relieve irritability and anxiety associated with premenstrual stress13  and has been shown to enhance rapid recovery from major depressive disorder14.


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References:
 

1 Note: the scientific research presented herein is intended to help further understand the ingredients of the Edge7 products and are not intended as implicit claims of efficacy.

2 Abdou AM, Higashiguchi S, Horie K, Kim M, Hatta H, Yokogoshi H. Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans. Bio-factors. 2006;26(3):201-208.

3 Juneja L. L-theanine—a unique amino acid of green tea and its relaxation effect in humans. Trends Food Sci Technol. 1999;10(6-7):199-204. doi:10.1016/S0924-2244(99)00044-8.

4 Kimura K, Ozeki M, Juneja LR, Ohira H. L-Theanine reduces psychological and physiological stress responses. Biol Psychol. 2007;74(1):39-45. doi:10.1016/j.biopsycho.2006.06.006.

5 Nathan PJ, Lu K, Gray M, Oliver C. The Neuropharmacology of L-Theanine( N -Ethyl-L-Glutamine). J Herb Pharmacother. 2015;6(2):21-30. doi:10.1080/J157v06n02_02.

6 Zhang CG, Kim S-J. Taurine induces anti-anxiety by activating strychnine-sensitive glycine receptor in vivo. Ann NutrMetab. 2007;51(4):379-386. doi:10.1159/000107687.

7 Chen SW, Kong WX, Zhang YJ, Li YL, Mi XJ, Mu XS. Possible anxiolytic effects of taurine in the mouse elevated plus-maze. Life Sci. 2004;75(12):1503-1511. doi:10.1016/j.lfs.2004.03.010.

8 Ajao MY, Akindele AJ. Anxiolytic and sedative properties of hydroethanolic extract of Telfairiaoccidentalis leaves in mice. Rev Bras Farmacogn. 2013;23(2):301-309. doi:10.1590/S0102-695X2012005000138.

9 Lakhan SE, Vieira KF. Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review.Nutr J. 2010;9:42. doi:10.1186/1475-2891-9-42.

10 Hasani N, Kazemi M, KarimiAfshar H, Kazemi M, Tavakoli M. Comparison of the Effects of Relaxation and Vitamin B6 on Emotional and Physical Symptoms in Premenstrual Syndrome. Evid Based Care. 2015;5(2):75-83.

11 Sartori SB, Whittle N, Hetzenauer A, Singewald N. Magnesium deficiency induces anxiety and HPA axis dysregulation: modulation by therapeutic drug treatment. Neuropharmacology. 2012;62(1):304-312. doi:10.1016/j.neuropharm.2011.07.027.

12 Jacka FN, Overland S, Stewart R, Tell GS, Bjelland I, Mykletun A. Association between magnesium intake and depression and anxiety in community-dwelling adults: the Hordaland Health Study. Aust N Z J Psychiatry. July 2009.

13 Fathizadeh N, Ebrahimi E, Valiani M, Tavakoli N, Yar MH. Evaluating the effect of magnesium and magnesium plus vitamin B6 supplement on the severity of premenstrual syndrome. Iran J Nurs Midwifery Res. 2010;15(Suppl 1):401-405.

14 Eby GA, Eby KL. Rapid recovery from major depression using magnesium treatment.Med Hypotheses. 2006;67(2):362-370. doi:10.1016/j.mehy.2006.01.047.