MAIN INGREDIENTS AND DOSAGE: (per daily dose of 2 capsules)
- Edge7 Move Formula: 900mg (contains L-Tyrosine, DL-Phenylalanine, L-Theanine)
- Caffeine: 85mg
- Vitamin B6 (Pyridoxine HCL): 10mg (714% Reference Intake)
L-Tyrosine, further referred to as tyrosine, is an amino acid used by the body for making a number of essential proteins, including the neurotransmitters dopamine and norepinephrine. These play a major role in the “fight or flight” response to stressful conditions and are essential in maintaining normal mood2. By increasing levels of these neurotransmitters, intake of tyrosine has shown in scientific studies to have a variety of cognition-enhancing effects, especially during stress3. Tyrosine has also been shown4 to improve cognition decline in sleep-deprived individuals, who continued to perform well 3 hours after tyrosine supplementation, despite 24 hours of sleep deprivation.Similar improvements have been observed in cognitive performance of cadets after one week of intensive combat training5.Tyrosine also enhances working memory6 in subjects exposed to cold. There is also evidence that suggests it can elevate mood in depressed individuals7.
Similar to tyrosine, DL-phenylalanine, also referred to as phenylanine, is a precursor to the neurotransmitters dopamine and norepinephrine. In addition, it is involved in the synthesis of the neurotransmitter serotonin. Its effects on cognition are similar to those of tyrosine.Depletion of phenylalanine from the diet is associated with increased impulsive behavior due to dopamine deficiency8.Supplementation with phenylalanine may reduce such impulsive behavior and improve self-control. Oral administration of this amino acid also improves attention in individuals9 with attention deficit disorder.
L-Theanine, or theanine, is an amino acid commonly found in green tea. Research suggests that the combination of theanine with caffeine has positive effects on mood and cognition, which surpass the effects of caffeine or theanine alone10.Further research suggests theanine enhances mood and cognitive performance. It also improves reaction time and visual processing, and contributes to reduced mental fatigue11.
Research on caffeine and cognition dates back to 1820. It has been clinically shown to help improve alertness, concentration and performance, with one study notably showing the effects of caffeine to be superior to those of a nap in terms of boosting verbal, motor and perceptual memory12.By acting on adenosine receptors in the brain, caffeine promotes wakefulness and arousal13. Through a similar mechanism, it increases reaction time14.Furthermore, a recent scientific review found that caffeine improves attention across a wide range of simple and complex attention tests15. The concentration of caffeine in Edge7 Move is equivalent to approximately one single shot of espresso.
Vitamin B6, is a vitamin used by the body for a variety of functions. Several studies have found that it helps reduce anxiety.A review on the effects of various supplements concluded that the use of Vitamin B6, in combination with other vitamins and minerals, effectively reduces anxiety and stress16.Similarly, vitamin B6 is shown to reduce both psychological and physiological symptoms of irritability and anxiety17.
1 Note: the scientific research presented herein is intended to help further understand the ingredients of the Edge7 products and are not intended as implicit claims of efficacy.
2 Ruhé HG, Mason NS, Schene AH. Mood is indirectly related to serotonin, norepinephrine and dopamine levels in humans: a meta-analysis of monoamine depletion studies. Mol Psychiatry. 2007;12(4):331-359.doi:10.1038/sj.mp.4001949.
3 Deijen J., Orlebeke J. Effect of tyrosine on cognitive function and blood pressure under stress. Brain Res Bull. 1994;33(3):319-323. doi:10.1016/0361-9230(94)90200-3.
4 Neri DF, Wiegmann D, Stanny RR, Shappell SA, McCardie A, McKay DL. The effects of tyrosine on cognitive performance during extended wakefulness. Aviat Space Environ Med. 1995;66(4):313-319
5 Deijen J., Wientjes CJ.,Vullinghs HF., Cloin P., Langefeld J. Tyrosine improves cognitive performance and reduces blood pressure in cadets after one week of a combat training course. Brain Res Bull. 1999;48(2):203-209. doi:10.1016/S0361-9230(98)00163-4.
6 Mahoney CR, Castellani J, Kramer FM, Young A, Lieberman HR. Tyrosine supplementation mitigates working memory decrements during cold exposure. PhysiolBehav. 2007;92(4):575-582. doi:10.1016/j.physbeh.2007.05.003.
7 Gelenberg AJ, Wojcik JD, Gibson CJ, Wurtman RJ. Tyrosine for depression.J Psychiatr Res. 17(2):175-180.
8 Ramdani C, Carbonnell L, Vidal F, Béranger C, Dagher A, Hasbroucq T. Dopamine precursors depletion impairs impulse control in healthy volunteers. Psychopharmacology (Berl). 2015;232(2):477-487. doi:10.1007/s00213-014-3686-z.
9 Hinz M, Stein A, Neff R, Weinberg R, Uncini T. Treatment of attention deficit hyperactivity disorder with monoamine amino acid precursors and organic cation transporter assay interpretation. Neuropsychiatr Dis Treat. 2011;7:31-38. doi:10.2147/NDT.S16270.
10 Owen GN, Parnell H, De Bruin EA, Rycroft JA. The combined effects of L-theanine and caffeine on cognitive performance and mood.NutrNeurosci. 2008;11(4):193-198. doi:10.1179/147683008X301513.
11 Haskell CF, Kennedy DO, Milne AL, Wesnes KA, Scholey AB. The effects of L-theanine, caffeine and their combination on cognition and mood.Biol Psychol. 2008;77(2):113-122. doi:10.1016/j.biopsycho.2007.09.008.
12 Mednick SC, Cai DJ, Kanady J, Drummond SPA. Comparing the benefits of caffeine, naps and placebo on verbal, motor and perceptual memory. Behav Brain Res. 2008;193(1):79-86. doi:10.1016/j.bbr.2008.04.028.
13 Huang Z-L, Qu W-M, Eguchi N, et al. Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine. Nat Neurosci. 2005;8(7):858-859. doi:10.1038/nn1491.
14 Higgins GA, Grzelak ME, Pond AJ, Cohen-Williams ME, Hodgson RA, Varty GB. The effect of caffeine to increase reaction time in the rat during a test of attention is mediated through antagonism of adenosine A2A receptors. Behav Brain Res. 2007;185(1):32-42. doi:10.1016/j.bbr.2007.07.013.
15 Einöther SJL, Giesbrecht T. Caffeine as an attention enhancer: reviewing existing assumptions. Psychopharmacology (Berl). 2013;225(2):251-274. doi:10.1007/s00213-012-2917-4.
16 Lakhan SE, Vieira KF. Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review.Nutr J. 2010;9:42. doi:10.1186/1475-2891-9-42.
17 Hasani N, Kazemi M, KarimiAfshar H, Kazemi M, Tavakoli M. Comparison of the Effects of Relaxation and Vitamin B6 on Emotional and Physical Symptoms in Premenstrual Syndrome. Evid Based Care. 2015;5(2):75-83.